Since 1994 I've owned 7 total, with 3 currently in my possession and am a member of all known English speaking Astro/Safari van forums.
Here are them main known issues.
Stock fuel pump goes out somewhere over 100k miles. These are in a 27 gallon tank that must be lowered in order to replace. It's not really that hard of a job though.
They eat idler arms. Buy Moog when the current ones get sloppy and keep them greased.
Door handles are made out of cheap pot metal and break. Lubricate the door mechanisms every few months so the pull never becomes stiff enough to require much force. I've never broke a handle on a van in my possession.
AWD vans, if the van has over 100k miles replace the seals on the front diff. I chewed up two diffs. One by not noticing a leak during the winter, the other by not acting upon it quickly enough.
Some of the AWD vans did come with an Eaton LSD in the rear diff. This would be designated by having G80 listed in the RPO codes.
Also the easiest engine removal is to disconnect the wiring harness, remove the sub-frame to body mounting bolts, then lifting the front of the van off it. From what I've seen a standard engine hoist is capable of lifting the front of the van off the sub-frame.
I'm currently driving a 1997 Astro AWD with 306k+ miles on it, that I purchased for $250. I have less than $800 total into the van and it's proving to be quite reliable.